Table 2.
Size characteristics, exposure concentrations and aerosol size distributions of generated aerosols for in vitro studies.
| Type of ENMs | Primary particle sizea | Concentration in Collison nebulizerc | Exposure concentration, mg/m3 |
Aerosol size distribution, GM nm, (GSD)b |
||||
|---|---|---|---|---|---|---|---|---|
| A549 | Co-culture | THP-1 | A549 | Co-culture | THP-1 | |||
| Citrate- capped Au – low | 18.36 ± 1.84 | 50 μg/mLd | 1.58 | – | – | 43.9 (1.8) | – | – |
| Citrate- capped Au – high | 18.36 ± 1.84 | 50 μg/mLd | 2.48 | – | – | 43.7 (1.7) | – | – |
| 15% Ag-SiO2 | 7.9 ± 4.3 (Ag) | 0.5 mg/mL | 4.73 | 4.48 | – | 84.5 (1.9) | 69.1 (2.0) | – |
| CuO | 50.24 ± 10.99 | 1.5 mg/mL | 3.62 | 3.93 | 1.81 | 35.4 (1.8) | 42.9 (1.8) | 42.4 (1.9) |
a
Primary particle size (geometric mean ± standard deviation) determined by transition electron microscopy provided by ERCC.
b
GM: geometric mean mobility diameter (GM) with geometric standard deviation (GSD).
c
All ENMs except Au were suspended in Optima ultrapure water.
d
Au suspension was used as provided.