Table 2.
Baseline electrolyte abnormalities' effect on primary endpoints
| OR | 95% CI | p | ||
|---|---|---|---|---|
| Requirement for ICU, n (%) | ||||
| Hyponatraemia | 25/146 (17.1) | 3.73 | 1.93–7.21 | <0.001 |
| Hypokalaemia | 5/28 (17.8) | 2.48 | 0.88–7.0 | 0.08 |
| Hyperkalaemia | 2/7 (28.5) | 4.18 | 0.78–22.35 | 0.09 |
| Hypochloraemia | 11/28 (39.2) | 8.81 | 3.74–20.74 | <0.001 |
| Hypocalcaemia | 11/39 (28.2) | 5.18 | 2.32–11.57 | <0.001 |
| Requirement for MV, n (%) | ||||
| Hyponatraemia | 18/146 (12.3) | 3.20 | 1.47–6.99 | 0.003 |
| Hypokalaemia | 4/28 (14.2) | 2.32 | 0.74–7.2 | 0.14 |
| Hyperkalaemia | 0/7 (0.0) | N/A | N/A | N/A |
| Hypochloraemia | 9/28 (32.4) | 6.23 | 2.58–15.04 | <0.001 |
| Hypocalcaemia | 9/39 (23.0) | 5.23 | 2.19–12.5 | <0.001 |
| Mortality, n (%) | ||||
| Hyponatraemia | 19/146 (13.0) | 5.40 | 2.21–13.20 | <0.001 |
| Hypokalaemia | 2/28 (7.1) | 1.15 | 0.25–5.14 | 0.85 |
| Hyperkalaemia | 0/7 (0.0) | N/A | N/A | N/A |
| Hypochloraemia | 6/28 (21.4) | 5.08 | 1.84–14.00 | 0.001 |
| Hypocalcaemia | 8/39 (20.5) | 5.14 | 2.06–12.80 | <0.001 |
| Duration of hospitalization (days)a | ||||
| Hyponatraemia | 8.72 ± 5.74 | 1.06 | 1.03–1.12 | 0.001 |
| Hypokalaemia | 7.51 ± 4.64 | 0.98 | 0.93–1.06 | 0.80 |
| Hyperkalaemia | 9.24 ± 4.40 | 1.02 | 0.95–1.12 | 0.40 |
| Hypochloraemia | 12.75 ± 6.79 | 1.09 | 1.04–1.14 | <0.001 |
| Hypocalcaemia | 11.35 ± 9.36 | 1.08 | 1.04–1.12 | <0.001 |
Abbreviations: ICU, intensive care unit; MV, mechanical ventilation.