Table 3.
The validation parameters and chromatographic properties of MRP and NDM determination methods from plasma samples in literature
| Study | Analytes | LOQ (ng/mL) | Accuracy (RE%) | Precision (RSD%) | Recovery (%) | Retention times (min) | Linearity (ng/mL) | Mobile phase | Extraction type | Flow (mL/min) | Instrument - detector | Amount of used plasma (µL) | Total analysis time (min) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ptacek et al. (2003) [3] |
MRP | 1.5 | (-1.2) – (6.5) | MRP, ≤4.9 | - | - | 2 - 151 | ACN:30mM PB (2% TEA and SA) pH:4.0 | LLE | 1 | HPLC-FL | 1000 | 4 |
| NDM | - | - | - | - | - | ||||||||
| Romingueres et al. (2002) [5] |
MRP | 20 | (-4.2) – 2.0 | ≤8.3 | 96.9 | 4.2 | 50 - 500 | ACN: 6.24 mM PB, pH:6.4 | LLE | 0.8 | HPLC-UV | 1000 | 12 |
| NDM | 20 | (-9.9) – 1.1 | ≤6.1 | 102.9 | 2.6 | 50 - 500 | |||||||
| Lavasani et al (2014) [6] |
MRP | 1 | (-9.98) - 18.3 | ≤12.9 | 86.9 | 3.5 | 1 - 500 | ACN: 25mM PB, pH:3.0 (20:80, v/v) | LLE | 2 | HPLC-FL | 150 | 5 |
| NDM | 2 | (-18.9) - 6.8 | ≤16.7 | 37.2 | 3.0 | 2 - 500 | |||||||
| Frahnert et al. (2003) [18] |
MRP | - | - | ≤7.7 | 97.9 | 16.6 | 5 - 300 | ACN: 25mM PB pH:7.0 (40:60, v/v) | SPE | 1 | HPLC-UV | 1000 | - |
| NDM | - | - | - | - | 8.3 | - | |||||||
| Titier et al. (2003) [21] |
MRP | 25 | (-5.5) – (-5.1) | ≤11.5 | 80.5 | 5.8 | 25-500 | ACN: 10mM PB pH 3.8 | LLE | 1 | HPLC-PDA | 1000 | 18 |
| NDM | 25 | (-5.5) – (-3.0) | ≤12.0 | 64.0 | 5.4 | 25-500 | |||||||
| Duvernoil et al. (2003) [22] |
MRP | 25 | (-0.6) – 5.3 | ≤4.74 | 102.0 | 6.5 | 25 - 1000 | ACN: PB pH:3.8 | LLE | 1 | HPLC-PDA | 1000 | 18 |
| NDM | 20 | - | - | - | - | - | |||||||
| Pongtanya et al. (2012) [23] |
MRP | 3 | <15 | <15 | - | - | 3 - 300 | MeOH:water (0.00002% TFA) | LLE | 1 | HPLC-DAD | 1000 | - |
| NDM | - | - | - | - | - | - | |||||||
| Dallet et al. (2002) [24] |
MRP | - | - | - | - | - | - | ACN: 25mM PB, pH: 4.8 (10mM TEA) (66:35, v/v) | - | 1 | HPLC-PDA | - | 20 |
| NDM | - | - | - | - | - | - | |||||||
| Our developed method | MRP | 0.52 | (-0.6) – 5.5 | < 3.4 | 94.4 | 7.3 | 10 – 250 | MP-A: ACN: 20 mM PB, triethylamine (75:24:1, v/v/v) pH 4.3 MP-B: ACN |
LLE | 1.2 | HPLC-UV | 500 | 12 |
| NDM | 0.46 | (-2.8) – 3.7 | < 2.9 | 107.0 | 6.7 | 10 - 250 |
ACN: Acetonitrile; PB: Phosphate buffer; LLE: Liquid-liquid extraction; SPE: Solid-phase extraction; HPLC: High performance liquid
chromatography; FL: Flourescent; PDA: Photo diod array; TEA: Triethylamine, TFA: Triflouroacetic acid, SA: Sodium azide, MP: mobile phase.