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. 2020 Winter;19(1):487–506. doi: 10.22037/ijpr.2019.13084.11362

Scheme 1.

Scheme 1

Outline for the synthesis of 3-({5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(un/substituted-phenyl)propanamides. Reagents and Conditions: (I) MeOH/N2H4·H2O/refluxing for 2 h. (II) EtOH/CS2/KOH/refluxing for 5 h. (III) Aq. 10% Na2CO3 soln./vigorous manual shaking and stirring at RT for 2-3 h. (IV) DMF/LiH/stirring for 3-5