Table 2.

Effect of 70% ethanol leaf extract of O. fruticosa on tail immersion model in mice

Groups	Latency (s) ± SEM
	0	30	60	90	120	150	180
Sunflower oil	2.91 ± 0.23	2.47 ± 0.17	2.72 ± 0.26	2.55 ± 0.14	2.67 ± 0.21	2.60 ± 0.21	2.33 ± 0.14
OF 100 mg/kg	3.23 ± 0.06	4.27 ± 0.43a2b3c1d3	4.85 ± 0.36a2b3c1d3	5.22 ± 0.47a2b3c1d3	6.65 ± 0.78a3b3d3	7.27 ± 0.48a3b2c1d3	6.78 ± 0.49a3 b2 d3
OF 200 mg/kg	2.70 ± 0.17	5.92 ± 0.53a3b3d3	6.38 ± 0.53a3 b3d3	7.12 ± 0.71 a3 b3d3	7.80 ± 0.67a3 b3d3	9.50 ± 0.98a3d2	8.00 ± 0.95a3b1d2
OF 400 mg/kg	2.82 ± 0.22	10.58 ± 0.20a3 b3	10.97 ± 0.23a3b3	11.23 ± 0.21a3	11.50 ± 0.33a3	12.35 ± 0.41a3	11.15 ± 0.29a3
Pethidine 5 mg/kg	3.40 ± 0.34	14.17 ± 0.09a3	13.27 ± 0.11a3	12.43 ± 0.16a3	11.92 ± 0.03a3	10.80 ± 0.21a3	10.25 ± 0.21a3

Data represent mean ± SEM (n = 6); ¹p < 0.05, ²p < 0.01, ³p < 0.001; ^arelative to control; ^brelative to standard; ^crelative to 200 mg/kg; ^drelative to 400 mg/kg. OF: 70% ethanol extract of Otostegia fruticosa.