Table 3.
Effect of the organic solvent fractions of 70% ethanol leaf extract of O. fruticosa on tail immersion model in mice
| Groups |
Latency (s) ± SEM
|
||||||
|---|---|---|---|---|---|---|---|
| 0 | 30 | 60 | 90 | 120 | 150 | 180 | |
| Sunflower oil | 3.83 ± 0.16 | 2.63 ± 0.19 | 2.41 ± 0.18 | 2.00 ± 0.11 | 2.70 ± 0.19 | 2.83 ± 0.21 | 2.07 ± 0.17 |
| HF400 mg/kg | 3.58 ± 0.26 | 4.33 ± 0.28b3c3d3 | 4.68 ± 0.34a2b3c3d3 | 6.17 ± 0.21a3b3c3d3 | 5.53 ± 0.27a2b3c3d3 | 5.53 ± 0.31a2b3c3d3 | 5.20 ± 0.43a2b3c3d3 |
| EF400 mg/kg | 8.78 ± 5.45 | 4.51 ± 0.44a1b3c3d3 | 5.50 ± 0.49a3b3c3d3 | 7.22 ± 0.35a3b3c2d2 | 6.67 ± 0.45 a3b2c3d3 | 6.43 ± 0.46a3b3c3d3 | 6.20 ± 0.41a3b3c2d3 |
| CF400 mg/kg | 3.83 ± 0.17 | 8.00 ± 0.45a3b3 | 9.22 ± 0.47a3b2 | 9.82 ± 0.49a3 | 12.00 ± 0.73 a3 | 10.08 ± 0.49a3 | 9.17 ± 0.60a3 |
| BF400 mg/kg | 3.80 ± 0.19 | 7.93 ± 0.48a3b3 | 9.13 ± 0.44a3b2 | 9.83 ± 0.40a3 | 11.67 ± 0.56 a3 | 10.33 ± 0.42a3 | 9.58 ± 0.37a3 |
| Pethidine 5 mg/kg | 4.20 ± 0.35 | 12.83 ± 0.48a3 | 11.45 ± 0.49a3 | 10.92 ± 0.73a3 | 10.20 ± 0.68a3 | 9.90 ± 0.64a3 | 9.63 ± 0.65a3 |
Data represent mean ± SEM (n = 6); 1p < 0.05, 2p < 0.01, 3p < 0.001; arelative to control; brelative to standard; crelative to BF 400 mg/kg; drelative to HF 400 mg/kg; CF: Chloroform fraction; EF: Ethyl acetate fraction; BF: Buthanol fraction; HF: Hydromethanol fraction; ASA: acetylsalicylic acid.