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. 2020 Sep 1;32(9):108103. doi: 10.1016/j.celrep.2020.108103

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© 2020 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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OSNs Induce Strong Antiviral Responses upon Infection

(A) Representative fluorescence-activated cell sorting (FACS) gating strategy to isolate live EpCam⁺ OMP⁺ OSNs from the OE of Mock- and Mal/04-Cre-infected mice is shown. For sequencing, tissues from three independent mice per time point were collected and pooled at 0, 3, and 14 days post-infection for mock, actively infected, and previously infected treatment groups, respectively.

(B) Reads mapped to the Mal/04 genome (shown in red) and Gapdh (shown in gray) and normalized to total reads in the Mock (0) and tdTomato⁺ cell population at 3 and 14 days post-infection.

(C) Heatmap of top significantly differentially expressed genes as ranked by a Benjamini-Hochberg adjusted p value. All “Olfr-” genes were excluded manually prior to analysis to account for sampling variability.

(D) Gene ontology analysis (PANTHER) of both upregulated and downregulated genes in infected OSNs.

(E) Heatmap of differentially expressed genes from an independent list (Schoggins et al., 2014) of interferon-stimulated antiviral genes. Rep, biological replicate.