Table 2.
ROTEM® variables and conventional coagulation variables in COVID-19 patients with and without thromboembolic complications.
| ROTEM® parameter | Normal range | All COVID-19 patients (n = 47), mean (SD) | Thromboembolic complications (n = 10), mean (SD) | No thromboembolic complications (n = 37), mean (SD) |
P-value |
|---|---|---|---|---|---|
| EXTEM | |||||
| CT, s | 53–83 | 85.5 (20.6) | 95.7 (17.4) | 82.8 (20.8) | 0.08 |
| CFT, s | 46–149 | 45.3 (10.0) | 54.1 (8.4) | 42.9 (9.2) | 0.001 |
| A5, mm | 32–52 | 63.1 (6.4) | 58.5 (7.8) | 64.3 (5.4) | 0.01 |
| A10, mm | 43–63 | 71.5 (5.3) | 68.0 (7.2) | 72.4 (4.4) | 0.02 |
| MCF, mm | 55–72 | 77.3 (4.1) | 75.0 (5.9) | 77.9 (3.3) | 0.05 |
| INTEM | |||||
| CT, s | 168–212 | 177.6 (25.0) | 184.5 (18.5) | 175.7 (26.3) | 0.30 |
| CFT, s | 62–130 | 45.6 (12.8) | 53.3 (15.9) | 43.5 (11.2) | 0.03 |
| A5, mm | 33–52 | 55.8 (7.4) | 51.4 (8.4) | 57.0 (6.7) | 0.03 |
| A10, mm | 43–62 | 65.3 (6.4) | 61.6 (7.5) | 66.2 (5.8) | 0.04 |
| MCF, mm | 51–69 | 72.9 (5.0) | 70.5 (6.1) | 73.5 (4.5) | 0.09 |
| FIBTEM | |||||
| MCF, mm | 6–21 | 32.9 (6.4) | 31.1 (8.3) | 33.3 (5.8) | 0.33 |
| Conventional coagulation variables | |||||
| Platelet count, 109/L | 150–400 | 404 (154) | 350 (208) | 419 (135) | 0.21 |
| PT, s | 10.2–13.3 | 15.3 (2.0) | 14.9 (2.1) | 15.4 (1.9) | 0.47 |
| APTT, s | 25–36 | 34.7 (8.7) | 32.6 (3.4) | 35.3 (9.6) | 0.40 |
| Fibrinogen, g/L | 2.0–3.9 | 7.2 (1.6) | 7.1 (1.9) | 7.3 (1,5) | 0.76 |
Abbreviations: ROTEM® = rotational thromboelastometry; INTEM = intrinsic rotational thromboelastometry; EXTEM = extrinsic rotational thromboelastometry; FIBTEM = fibrinogen rotational thromboelastometry; CT = clotting time; CFT = clot formation time; A5 = amplitude after 5 min; A10 = amplitude after 10 min; MCF = maximum clot firmness; PT = prothrombin time; APTT = activated partial thromboplastin time.