Appendix 2—chemical structure 5. 2-(2-((6-(1H-pyrazol-1-yl)pyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide (HQ008).

Pale yellow solid; Yield 25%; ¹H NMR (400 MHz, DMSO-d₆) δ 12.09 (s, 1H), 11.63 (s, 1H), 8.75 (d, J = 2.2 Hz, 1H), 7.91–7.81 (m, 2H), 7.42 (d, J = 7.9 Hz, 1H), 7.14 (s, 1H), 6.94–6.88 (m, 2H), 6.64 (s, 1H), 3.80 (s, 2H), 2.33 (s, 3H); HRMS (m/z): [M+H]⁺ calculated for C₁₇H₁₆N₇OS₂, 398.0852; found, 398.0882.