Appendix 1—chemical structure 6. 2-(2-((6-chloropyridin-2-yl)amino)thiazol-4-yl)-N-(5-methylthiazol-2-yl)acetamide (HQ002).

Pale yellow solid; Yield 35%; ¹H NMR (400 MHz, CDCl₃: CD₃OD = 4:1) δ 7.52 (dt, J = 11.0, 7.6 Hz, 1H), 7.01 (s, 1H), 6.89–6.82 (t, J = 7.2 Hz, 1H), 6.78 (dd, J = 8.2, 3.2 Hz, 1H), 6.58 (s, 1H), 3.76 (s, 2H), 2.35 (s, 3H). HRMS (m/z): [M+H]⁺ calculated for C₁₄H₁₃ClN₅OS₂, 366.0245; found, 366.0265.