Table 5.
Effect of Missing Values on Risk Discrimination Using REVEAL Lite 2a
| Lite 2 Model Description | Variables Included in the Model (N = 2,529; Missing Value Assumed of 0 Risk Score) | C-Index (95% CI) |
|---|---|---|
| All 6 parameters/variables included | BNP/NT-proBNP, 6MWD, NYHA or WHO FC, SBP < 110 mm Hg, HR >96 bpm, renal insufficiency | 0.73 (0.71-0.75) |
| Missing 1 parameter/variable | ||
| No BNP/NT-proBNP | 6MWD, NYHA/WHO FC, SBP <110 mm Hg, HR > 96 bpm, renal insufficiency | 0.70 (0.68-0.72) |
| No 6MWD | BNP/NT-proBNP, NYHA or WHO FC, SBP < 110 mm Hg, HR > 96 bpm, renal insufficiency | 0.71 (0.69-0.73) |
| No NYHA or WHO FC | BNP/NT-proBNP, 6MWD, SBP < 110 mm Hg, HR > 96 bpm, renal insufficiency | 0.72 (0.70-0.74) |
| No HR | BNP/NT-proBNP, 6MWD, NYHA or WHO FC, SBP < 110 mm Hg, renal insufficiency | 0.73 (0.71-0.75) |
| No renal insufficiency | BNP/NT-proBNP, 6MWD, NYHA or WHO FC, SBP < 110 mm Hg, HR > 96 bpm | 0.73 (0.71-0.75) |
| No SBP | BNP/NT-proBNP, 6MWD, NYHA or WHO FC, HR > 96 bpm, renal insufficiency | 0.73 (0.71-0.75) |
| Missing 2 parameters from top 3 parameters or variables BNP/NT-proBNP, 6MWD, and NYHA or WHO FC | ||
| Lite 2 (no BNP and 6MWD) | NYHA/WHO FC, SBP < 110 mm Hg, HR > 96, renal insufficiency | 0.67 (0.65-0.69) |
| Lite 2 (no NYHA and 6MWD) | BNP, SBP < 110 mm Hg, HR > 96, renal insufficiency | 0.68 (0.66-0.70) |
| Lite 2 (no NYHA and BNP) | 6MWD, SBP < 110 mm Hg, HR > 96, renal insufficiency | 0.69 (0.67-0.71) |
| Missing 2 parameters or variables from SBP, renal insufficiency, and HR | ||
| Missing SBP and renal insufficiency | BNP/NT-proBNP, 6MWD, NYHA or WHO FC, HR > 96 bpm | 0.72 (0.70-0.74) |
| Missing HR and SBP | BNP/NT-proBNP, 6MWD, NYHA or WHO FC, renal insufficiency | 0.73 (0.71-0.75) |
| Missing HR and renal insufficiency | BNP/NT-proBNP, 6MWD, NYHA or WHO FC, SBP < 110 mm Hg | 0.72 (0.70-0.74) |
| Missing SBP, renal insufficiency, and HR (3 parameters or variables) | BNP/NT-proBNP, 6MWD, NYHA or WHO FC | 0.72 (0.70-0.74) |