Table 3.
Summary of reported adverse effects in both the groups of all seven studies.
| Study | Patients in Treatment group (n) | Adverse effect in Treatment group(n) | Patients in Control group(n) | Adverse effect in Control group(n) |
|---|---|---|---|---|
| Chen J et al. | 15 | Diarrhea (2) Disease progression (1) Elevated AST (1) |
15 | Elevated ALT (1) Elevated creatinine (1) Anemia (1) |
| Chen Z et al. | 31 | Rash (1) Headache (1) |
31 | None |
| Huang et al. | 10 | NR | 12 | NR |
| W Tang et al. | 70 | Serious adverse effects (2) Disease progression (1) Upper respiratory infection (1) Non serious adverse effects (19) Diarrhea (7) Vomiting (2) Other mild adverse effects (10) |
80 | Serious adverse effects (0) Non serious adverse effects (7) |
| Cavalcanti et al. | 159 | QTc prolongation (13) Arrythmia (3) Bradycardia (1) Supraventricular tachycardia (2) Pulmonary Embolism (1) Nausea (9) Bloodstream infection (1) Anemia (14) Elevated ALT or AST level (17) Hypoglycemia (1) Elevated bilirubin level (5) Leukopenia (3) |
173 | QTc prolongation (1) Arrythmia (1) Bradycardia (1) Brochospasm (1) Nausea (2) Vomiting (1) Anemia (11) Elevated ALT or AST level (6) Elevated bilirubin level (2) Leukopenia (3) |
| Oriol et al. | 136 | Gastrointestinal disorders (7), Nervous system disorders (3), Infections (12) Metabolism and Nutritional disorders (1) General disorders (1) |
157 | Gastrointestinal disorders (148) Ear and Labrynth disorders (5) Eye disorders (5) Infections (9) Metabolism and Nutritional disorders (2) General disorders (30) Injury, poisoning and procedural complications (1) Metabolism and nutrition disorders (2) Musculoskeletal and connective tissue disorders (1) Nervous system disorders (63) Psychiatric disorders (2) Renal and urinary disorders (1) Reproductive system and breast disorders (1) Respiratory, thoracic and mediastinal disorders Skin and subcutaneous tissue disorders (11) Vascular disorders (1) |
| Horby P et al. | 1561 | Cardiac Arrythmia (698) Supraventriclar tachycardia (48) Ventricular tachycardia (6) Atrioventricular block (6) Torsades de Pointes (1)∖ |
3155 | Cardiac Arrythmia (1357) Supraventriclar tachycardia (80) Ventricular tachycardia (9) Atrioventricular block (13) |
NR Not reported, ALT Alanine aminotransferase, AST Aspartate aminotransferase.