Table 2.
Polyp occurrence in the GI tract.
| Index patients | Nonindex patients | |||||
|---|---|---|---|---|---|---|
| Totala | Total with featureb | Totala | Total with featureb | |||
| n | n (% of total) | Median age (years)c (IQR) | n | n (% of total) | Median age (years)c (IQR) | |
| JP in stomach | 126 | 35 (27.8%) | 40.0 (16.0) | 95 | 23 (24.2%) | 42.0 (19.0) |
| SMAD4 | 71 | 28 (39.4%) | 40.0 (13.5) | 56 | 21 (37.5%) | 41.0 (14.8) |
| BMPR1A | 55 | 7 (12.7%) | 35.5 (28.0) | 39 | 2 (5.1%) | 56.5 (11.0) |
| JP in small intestine | 126 | 13 (10.3%) | 24.0 (26.5) | 95 | 10 (10.5%) | 46.0 (22.5) |
| SMAD4 | 71 | 10 (14.1%) | 29.0 (18.5) | 56 | 10 (17.9%) | 46.0 (22.5) |
| BMPR1A | 55 | 3 (5.5%) | 14.0 (30.0) | 39 | 0 | |
| JP in colon | 126 | 111 (88.1%) | 18.0 (25.0) | 95 | 45 (47.4%) | 20.0 (30.8) |
| SMAD4 | 71 | 61 (85.9%) | 19.0 (24.5) | 56 | 29 (51.8%) | 30.5 (35.0) |
| BMPR1A | 55 | 50 (90.9%) | 18.0 (23.3) | 39 | 16 (41%) | 16.0 (31.0) |
| JP in rectum | 126 | 58 (46.0%) | 18.5 (28.0) | 95 | 12 (12.6%) | 13.0 (15.0) |
| SMAD4 | 71 | 30 (42.3%) | 14.0 (28.8) | 56 | 7 (12.5%) | 6.0 (11.8) |
| BMPR1A | 55 | 28 (50.9%) | 19.0 (27.8) | 39 | 5 (12.8%) | 15.0 (22.0) |
| Other types of polypsd | 126 | 58 (46.0%) | 23.0 (23.0) | 95 | 25 (26.3%) | 40.0 (29.0) |
| SMAD4 | 71 | 30 (42.3%) | 23.0 (24.0) | 56 | 16 (28.6%) | 42.0 (25.0) |
| BMPR1A | 55 | 28 (50.9%) | 23.0 (20.5) | 39 | 9 (23.1%) | 31.0 (41.0) |
GI gastrointestinal, IQR interquartile range, JP juvenile polyp.
aTotal number of patients.
bTotal number of index or nonindex patients who presented with the respective symptom.
cDue to missing age at diagnosis the calculation of the median age is often based on fewer than the total number of patients with the respective feature.
dAdenomas, serrated and other polyps.