Table 2. Univariable and Multivariable Cox Regression Analysis for CEFS in Total Cohort.
| Univariable Cox Regression Analysis | Multivariable Cox Regression Analysis | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age | 1.030 | 0.988–1.074 | 0.165* | Stepwise eliminated | ||
| Sex | 0.015* | 0.004 | ||||
| Male | 4.778 | 1.347–16.945 | 9.264 | 2.021–42.457 | ||
| Female | 1.000 | Reference | 1.000 | Reference | ||
| Hypertension | 0.006* | Stepwise eliminated | ||||
| Yes | 4.499 | 1.530–13.229 | ||||
| No | 1.000 | Reference | ||||
| DM | 0.174* | Stepwise eliminated | ||||
| Yes | 2.021 | 0.732–5.577 | ||||
| No | 1.000 | Reference | ||||
| ESR (mm/hr) | 0.996 | 0.971–1.022 | 0.767 | |||
| CRP (mg/dL) | 1.135 | 1.072–1.201 | < 0.001* | 1.080 | 1.010–1.156 | 0.025 |
| WBC (cells/μL) | 1.000 | 1.000–1.000 | 0.002* | Stepwise eliminated | ||
| Total lung volume (mL) | 0.999 | 0.999–1.000 | 0.033* | Stepwise eliminated | ||
| Emphysema % | 0.901 | 0.742–1.094 | 0.293 | |||
| NALP (%) | 0.936 | 0.913–0.960 | < 0.001* | Stepwise eliminated | ||
| CALP (%) | 1.066 | 1.040–1.093 | < 0.001* | 1.067 | 1.033–1.101 | < 0.001 |
| Emphysema volume (mL) | 0.998 | 0.993–1.002 | 0.321 | |||
| NALPV (mL) | 0.999 | 0.999–1.000 | 0.001* | Stepwise eliminated | ||
| CALPV (mL) | 1.005 | 1.003–1.007 | < 0.001* | Stepwise eliminated | ||
*Variables with p value < 0.2 on univariable analysis were included in multivariable analysis. CEFS = critical event-free survival, HR = hazard ratio, CI = confidence interval