Fig. 2.

Association of ACE2 expression with oncogenic pathways and tumor phenotypes in cancer. ACE2 expression levels are likely to inversely correlate with the activity of oncogenic pathways (A), MKI67 expression levels (B), stemness scores (C), and EMT signature scores (D) in cancer. EMT: epithelial-mesenchymal transition; (E) Kaplan-Meier survival curves showing that ACE2 upregulation is associated with favorable survival in pan-cancer and multiple individual cancer types. Log-rank test p-values are shown. OS: overall survival; DSS: disease-specific survival; PFI: progression-free interval; DFI: disease-free interval. (F) ACE2 expression levels significantly decrease with tumor advancement in KIRC. KIRC: kidney renal clear cell carcinoma.