Fig. 3.

Interaction networks of ACE2 in cancer. (A) 217 and 26 genes having marked positive and negative expression correlations with ACE2 in pan-cancer, respectively (|r| > 0.5). The size of nodes is proportional to the absolute values of the expression correlation coefficients. (B) Gene modules (gene ontology) enriched in high-ACE2-expression-level and low-ACE2-expression-level pan-cancer. (C) Co-expression subnetwork of the immune response module (in brown) enriched in high-ACE2-expression-level pan-cancer centered on three transcription factor genes (EOMES, IRF4, and TBX21).