Table 2.

Recommended dose of remdesivir based on the U.S. Food and Drug Administration formulation [45]

Weight (kg)	Require invasive mechanical ventilation and/or ECMO	Dosage	Formulation	Duration
				Day	Infusion bag volumeb)	Infusion time (min)	Rate infusion (mL/min)
3.5–40	No	5 mg/kg IV (single dose)	Remdesivir for injection, 100 mg, lyophilized powder only (Reconstitute with 19 mL of Sterile Water for Injection and dilute in 0.9% saline prior to administration)	Day 1	100 mL	30	3.33
						60	1.67
		2.5 mg/kg IV (single dose)		Days 2–5a)		120	0.83
					50 mL	30	1.67
3.5–40	Yes	5 mg/kg IV (single dose)		Day 1		60	0.83
						120	0.42
		2.5 mg/kg IV (single dose)		Days 2–10	25 mL	30	0.83
						60	0.42
						120	0.21
≥40	No	200 mg IV (single dose)	Remdesivir injection (Dilute remdesivir injection concentrated solution in 0.9% saline prior to administration) or remdesivir for injection	Day 1	250 mL	30	8.33
						60	4.17
		100 mg IV (single dose)		Days 2–5a)		120	2.08
≥40	Yes	200 mg IV (single dose)		Day 1	100 mL	30	3.33
						60	1.67
		100 mg IV (single dose)		Days 2–10		120	0.83

ECMO, extracorporeal membrane oxygenation; IV, intravenous.

^a)May be extended up to 5 extra days if no clinical improvement is seen.

^b)The total volume in several options of infusion bag packages.