Table 2.

Multivariate analysis predicting overall survival using different hematologic variables.

	Model 1: iFLC and dFLC C-statistic = 0.6575 AUC = 0.6824 n = 305		Model 2: IFE and FLCR C-statistic = 0.6973 AUC = 0.7070 n = 268		Model 3: IFE, iFLC and dFLC C-statistic = 0.7136 AUC = 0.7354 n = 305
Variable	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
IFE negative			0.320 (0.590, 0.637)	0.0012	0.374 (0.202, 0.690)	0.0017
Normal FLCR			0.590 (0.345, 1.007)	0.0532
iFLC < 20 mg/L	0.199 (0.093, 0.425)	<0.0001			0.199 (0.092, 0.434)	<0.0001
dFLC < 10 mg/L	1.043 (0.562, 1.934)	0.8949			1.528 (0.787, 2.967)	0.2106

IFE absence of monoclonal protein in serum and urine immunofixation electrophoresis, FLCR free light chain ratio, iFLC involved free light chain level, dFLC difference in involved and uninvolved free light chain level, C-Statistic concordance, AUC area under the curve, HR hazard ratio, CI confidence interval.

Bold denotes statistically significant value.