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. 2020 Jun 16;123(5):752–761. doi: 10.1038/s41416-020-0934-3

Fig. 2. Cetuximab induces NK-cell mediated killing through ADCC in HNSCC cell lines.

Fig. 2

Cell index (CI) of the SCC22b-PBS (a) and SCC22b-R (b) was measured using the xCELLigence RTCA. Following overnight incubation, HNSCC cell lines were treated with an isotype control (hIgG1κ) or cetuximab [2 µg/ml], with or without NK92 cells (effector to target (E:T) ratio of 5:1), and CI was monitored for 48-h post-treatment (c). Both CD16+ and CD16− NK92 cells were used. CI was normalised to the time point were treatments (isotype control, cetuximab and/or NK92 cells) were added. Graphs represent mean ± SEM for each time point of follow up. Statistical significance between cell lines was tested using a linear mixed model with Tukey’s pairwise comparison. NS not significant; ***p < 0.001.