Table 1.
Echocardiographic, hemodynamic and morphometric parameters measured at euthanasia day (mean ± SD).
| Parameter | Early PAH rats (n = 8) |
Non-PAH matched control rats (n = 8) |
p value | End-stage PAH rats (n = 8) |
Non-PAH matched control rats (n = 8) |
p value |
|---|---|---|---|---|---|---|
| Echocardiographic measurements | ||||||
| Heart rate (bpm) | 515 ± 26.5 | 459 ± 52.9 | 0.018 | 434 ± 38.1 | 468 ± 57.2 | 0.184 |
| RVFWTd (mm) | 0.77 ± 0.04 | 0.57 ± 0.08 | < 0.001 | 1.03 ± 0.09 | 0.66 ± 0.03 | < 0.001 |
| TAPSE (mm) | 1.02 ± 0.13 | 1.43 ± 0.57 | 0.067 | 0.76 ± 0.13 | 1.21 ± 0.40 | 0.009 |
| PAAT/CL | 0.21 ± 0.06 | 0.23 ± 0.07 | 0.549 | 0.15 ± 0.06 | 0.22 ± 0.05 | 0.024 |
| Hemodynamic measurements | ||||||
| RV systolic pressure (mmHg) | 27.00 ± 4.93 | 18.43 ± 5.38 | 0.005 | 50.50 ± 11.56 | 21.57 ± 2.76 | < 0.001 |
| RV diastolic pressure (mmHg) | 8.43 ± 1.62 | 5.43 ± 2.64 | 0.016 | 5.00 ± 2.25 | 5.25 ± 1.75 | 0.808 |
| LV systolic pressure (mmHg) | 86.14 ± 7.58 | 90.71 ± 14.61 | 0.445 | 45.63 ± 9.10 | 93.00 ± 15.28 | < 0.001 |
| LV diastolic pressure (mmHg) | 8.71 ± 2.29 | 10.57 ± 5.22 | 0.371 | 6.25 ± 2.60 | 9.86 ± 5.49 | 0.115 |
| Morphometric measurements | ||||||
| RV free wall weight (g) | 0.21 ± 0.03 | 0.18 ± 0.02 | 0.034 | 0.36 ± 0.05 | 0.16 ± 0.04 | < 0.001 |
| LV free wall weight (g) | 0.35 ± 0.02 | 0.38 ± 0.05 | 0.137 | 0.25 ± 0.02 | 0.38 ± 0.07 | < 0.001 |
LV left ventricle, PAAT/CL pulmonary artery acceleration time normalized to cycle length, PAH pulmonary arterial hypertension, RV right ventricle, RVFWTd end-diastolic right ventricular free wall thickness, TAPSE tricuspid annular plane systolic excursion.
Statistically significant p values are given in bold.