Table 2.

Differentially expressed proteins in left and right ventricle myocardium of rats with early PAH (monocrotaline-induced) as compared to control non-PAH animals (p < 0.05, n = 4 per group).

Sample	UniProtKB ID	Gene name	Protein name	Fold change	Main biological process associated with the protein
Left ventricle myocardium	P14480	Fgb	Fibrinogen beta chain	2.19	Blood coagulation, adaptive immune response, acute-phase response, negative regulation of apoptotic process
	P06399	Fga	Fibrinogen alpha chain	2.14
	P02680	Fgg	Fibrinogen gamma chain	2.03
	P05544	Serpina3l	Serine protease inhibitor A3L	1.20	Negative regulation of endopeptidase activity, cell protection from oxidative stress-induced cell death, acute-phase response
	P05545	Serpina3k	Serine protease inhibitor A3K	1.16
	P02564	Myh7	Myosin-7	1.12	Fundamental contractile unit of cardiac muscle
	Q9QZ76	Mb	Myoglobin	1.11	response to hypoxia, facilitates the movement of oxygen within cardiomyocytes
	P56574	Idh2	Isocitrate dehydrogenase [NADP], mitochondrial	1.10	Intermediary metabolism and energy production, glyoxylate cycle
	P15650	Acadl	Long-chain specific acyl-CoA dehydrogenase, mitochondrial	1.09	Catalyzes the first step of mitochondrial fatty acid beta-oxidation pathway
	P13803	Etfa	Electron transfer flavoprotein subunit alpha, mitochondrial	1.09	Mitochondrial fatty acid beta-oxidation pathway, amino acid metabolism
	Q02253	Aldh6a1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	1.08	Valine and pyrimidine metabolism, binds fatty acyl-CoA
	P15429	Eno3	Beta-enolase	1.08	Glycolytic process, striated muscle development and regeneration
	P02563	Myh6	Myosin-6	−1.02	Cardiac muscle contraction
	P48675	Des	Desmin	−1.07	Intermediate filament organization
	P08733	Myl2	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform	−1.08	Cardiac muscle contraction
	P16617	Pgk1	Phosphoglycerate kinase 1	−1.10	Glycolytic pathway
	P16409	Myl3	Myosin light chain 3	−1.11	Regulation of cardiac muscle contraction
	P04642	Ldha	L-lactate dehydrogenase A chain	−1.11	Lactate metabolic process, positive regulation of apoptotic process
	P31977	Ezr	Ezrin	−1.21	Actin cytoskeleton reorganization
Right ventricle myocardium	P02564	Myh7	Myosin-7	1.17	Fundamental contractile unit of cardiac muscle
	P17764	Acat1	Acetyl-CoA acetyltransferase, mitochondrial	1.14	Catalyzes the last step of mitochondrial fatty acid beta-oxidation pathway
	Q02253	Aldh6a1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	1.12	Valine and pyrimidine metabolism, binds fatty acyl-CoA
	P15650	Acadl	Long-chain specific acyl-CoA dehydrogenase, mitochondrial	1.09	Catalyzes the first step of mitochondrial fatty acid beta-oxidation pathway
	P04642	Ldha	L-lactate dehydrogenase A chain	−1.12	Lactate metabolic process, positive regulation of apoptotic process
	O88767	Park7	Protein/nucleic acid deglycase DJ-1	−1.17	major nucleotide repair system, regulation of: cell death, apoptotic process, autophagy, oxidative stress