Table 3.
Differentially expressed proteins in left ventricle myocardium of rats with end-stage PAH (monocrotaline-induced) as compared to control non-PAH animals (p < 0.05, n = 4 per group).
| UniProtKB ID | Gene name | Protein name | Fold change |
|---|---|---|---|
| P01048 | Map1 | T-kininogen 1 | 1.30 |
| P09006 | Serpina3n | Serine protease inhibitor A3N | 1.26 |
| Q6LED0 | n/a | Histone H3.1 | 1.25 |
| Q64598 | n/a | Histone H2A type 1-F | 1.24 |
| P31000 | Vim | Vimentin | 1.23 |
| Q00715 | n/a | Histone H2B type 1 | 1.18 |
| P62804 | Hist1h4b | Histone H4 | 1.18 |
| Q4V8H8 | Ehd2 | EH domain-containing protein 2 | 1.17 |
| P02564 | Myh7 | Myosin-7 | 1.16 |
| Q07969 | Cd36 | Platelet glycoprotein 4 | 1.16 |
| P51868 | Casq2 | Calsequestrin-2 | 1.14 |
| Q62812 | Myh9 | Myosin-9 | 1.12 |
| Q9Z1P2 | Actn1 | Alpha-actinin-1 | 1.11 |
| B0LPN4 | Ryr2 | Ryanodine receptor 2 | 1.09 |
| P23965 | Eci1 | Enoyl-CoA delta isomerase 1, mitochondrial | 1.09 |
| Q64578 | Atp2a1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) | 1.07 |
| Q64428 | Hadha | Trifunctional enzyme subunit alpha, mitochondrial | 1.06 |
| P11507 | Atp2a2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) | 1.06 |
| P56741 | Mybpc3 | Myosin-binding protein C, cardiac-type | 1.05 |
| P10719 | Atp5f1b | ATP synthase subunit beta, mitochondrial | −1.06 |
| P00564 | Ckm | Creatine kinase M-type | −1.08 |
| P04797 | Gapdh | Glyceraldehyde-3-phosphate dehydrogenase | −1.09 |
| P15651 | Acads | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | −1.10 |
| P21396 | Maoa | Amine oxidase [flavin-containing] A | −1.13 |
| P12075 | Cox5b | Cytochrome c oxidase subunit 5B, mitochondrial | −1.13 |
| P05545 | Serpina3k | Serine protease inhibitor A3K | −1.15 |
| P02770 | Alb | Serum albumin | −1.16 |
| P26772 | Hspe1 | 10 kDa heat shock protein, mitochondrial | −1.16 |
| B2GV06 | Oxct1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | −1.17 |
| P55159 | Pon1 | Serum paraoxonase/arylesterase 1 | −1.19 |
| Q03626 | Mug1 | Murinoglobulin-1 | −1.22 |
| P14046 | A1i3 | Alpha-1-inhibitor 3 | −1.22 |