Table 2.
Level of regulation | GLUT2/Glut2 | GLUT5/Glut5 | SGLT1/Sglt1 |
---|---|---|---|
Transcription | Human: e.c.c.; rodents: in vivo | Human: e.c.c., C; rodents: in vivo | Human: e.c.c., C; pig: L; sheep: in vivo; rabbit: e.c.c.; rodents: in vivo |
mRNA stability | Human: C | Pig: L | |
Translation or protein stability | Rodents: in vivo (n.d.) | Rodents: in vivo (n.d.) | Sheep: in vivo (n.d.); rabbit: e.o. (p.s.) |
Protein trafficking | Rodents: in vivo | Human: e.o.; rabbit: e.o.; rodents: in vivo |
Different levels of regulation were investigated in different species in vivo and in vitro. For in vitro studies, two cell models and different expression systems were employed
C, measurements in Caco2 cells derived from human; L, measurements in LLCP-K1 cells derived from pig; e.o., transporter expression in oocytes of Xenopus laevis; e.c.c., transporter expression in cultivated cells; n.d., no differentiation between translation and protein stability was performed; p.s., protein stability was investigated