Table 2.
Overview of rodent diabetes models with reported GLUT2 expression
| Model | Obesity | GLUT2 expression | Reference |
|---|---|---|---|
| Goko-Kakizaki (GK) rats | No | GLUT2+ β-cells decreased | [81, 96] |
| Surface GLUT2 decreased | |||
| mRNA decreased | |||
| 3-OMG uptake reduced | |||
| Diabetic (db/db) mice | Yes | GLUT2+ β-cells decreased | [11, 146] |
| Protein decreased | |||
| mRNA decreased | |||
| Zucker Diabetic Fatty (ZDF) rats | Yes | mRNA decreased | [58, 98, 99, 104] |
| Protein decreased | |||
| GLUT2+ β-cells decreased | |||
| 3-OMG uptake reduced | |||
| STZ-induced rats | No | Protein decreased | [18, 145] |
| STZ-induced mice | No | mRNA decreased | [156] |
| Protein decreased | |||
| Dexamethasone-Induced (in Wistar and Zucker fatty rats) | No | GLUT2+ β-cells decreasedWD + ZD | [93, 97] |
| mRNA unalteredWD or elevatedZD | |||
| 3-OMG uptake reducedZD | |||
| DIO C57BL/6 mice | Yes | Protein decreased | [119] |
| Pancreatectomy in Sprague-Dawley rats | No | mRNA decreased | [167] |
| Protein decreased | |||
| BB/W rats | No | Protein decreased | [105] |
| GLUT2+ β-cells decreased |