Table 3.
Overview on the distribution of SGLT1 and SGLT2 in mouse, rat, and human pancreatic cells as well as pancreatic cell lines
| SGLT isoform | Species | Localization | Details and reference |
|---|---|---|---|
| SGLT1 | Mouse | Islet α-cells | SGLT1 mRNA and protein expression [9]. |
| SGLT1 protein expression [141]. | |||
| SGLT1 mRNA expression [137]. | |||
| Islet β-cells | Low SGLT1 mRNA expression levels [66]. | ||
| Islet δ-cells | Low SGLT1 mRNA expression levels [66]. | ||
| Islet cluster | Increased SGLT1 mRNA levels in islets isolated from ob/ob mice followed by a decline of expression levels in aged ob/ob mice [9]. | ||
| Low SGLT1 mRNA expression [66]. | |||
| SGLT1 mRNA and protein expression [141]. | |||
| Increased SGLT1 expression levels in db/db mice reported [141]. | |||
| Low SGLT1 mRNA expression levels [89]. | |||
| α-TC1 cell line | SGLT1 mRNA expression [137, 141]. | ||
| Increased SGLT1 expression levels at high glucose conditions reported [141]. | |||
| Pancreas in total | Low SGLT1 mRNA expression levels [80]. | ||
| Exocrine pancreas | SGLT1 protein expression in duct cells [80]. | ||
| Low SGLT1 mRNA expression levels [89]. | |||
| Human | Islet α-cells | SGLT1 mRNA and protein expression [9]. | |
| SGLT1 mRNA expression [27, 66, 133]. | |||
| Islet β-cells | Low SGLT1 mRNA expression levels [66]. | ||
| Islet cluster | Enriched SGLT1 mRNA levels in islets isolated from obese, glucose intolerant or T2D patients compared to lean controls reported [9]. | ||
| In contrast to SGLT1 in the murine islet and the findings observed for SGLT2, SGLT1 mRNA ratios remained elevated during the progression from insulin resistance to diabetes shown [9]. | |||
| SGLT1 mRNA and protein expression [137, 141]. | |||
| High variability of SGLT1 expression in human islet samples isolated from different donors. In average, SGLT1 mRNA transcripts are more abundant than SGLT2 mRNA transcripts reported [128]. | |||
| Rat | Islet cluster | Low levels SGLT1 mRNA expression [66]. | |
| Pancreas in total | Low SGLT1 mRNA expression levels [80]. | ||
| SGLT2 | Mouse | Islet α-cells | SGLT2 protein expression [9]. |
| Marginal, below the detection limit, SGLT2 mRNA signals reported [66]. | |||
| Few SGLT2 transcripts [151]. | |||
| Islet β-cells | Marginal, below the detection limit, SGLT2 mRNA signals reported [66]. | ||
| Few SGLT2 transcripts [151]. | |||
| Islet δ-cells | Specific expression of SGLT2 transcripts in 58% of δ-cell population reported [151]. | ||
| Marginal, below the detection limit, SGLT2 mRNA signals reported [66]. | |||
| α-TC1 cell line | SGLT2 mRNA and protein expression [62]. | ||
| Temporary high glucose concentrations resulted in an increase in SGLT2 mRNA and protein expression in murine α-TC1 cells. Culture up to 72 h at high glucose concentrations resulted in a decrease in SGLT2 mRNA and protein expression in murine α-TC1 cells reported [62]. | |||
| Islet cluster | SGLT2 mRNA expression [9]. | ||
| SGLT2 protein expression [9]. | |||
| SGLT2 expression increased in ob/ob mice from 5 to 8 weeks and declined at the age of 15 weeks when mice became overtly hyperglycemic reported [9]. | |||
| Human | Islet α-cells | SGLT2 mRNA and protein expression [9]. | |
| Enriched mRNA levels in islets isolated from obese, glucose intolerant or T2D patients compared to lean controls [9]. | |||
| Marginal, below the detection limit, SGLT2 mRNA signals reported [66]. | |||
| Few SGLT2 transcripts [151]. | |||
| Islet β-cells | Few SGLT2 transcripts [151]. | ||
| Marginal, below the detection limit, SGLT2 mRNA signals reported [66]. | |||
| Islet δ-cells | Specific expression of SGLT2 transcripts in 33% of δ-cell population reported [151]. | ||
| Marginal, below the detection limit, SGLT2 mRNA signals reported [66]. | |||
| Islet cluster | Marginal, below the detection limit, SGLT2 mRNA signals reported [66]. | ||
| SGLT2 mRNA expression [128]. | |||
| SGLT2 mRNA expression in human donors is highly heterogeneous [128]. | |||
| Pearson’s correlation underlines SGLT2 and glucagon colocalization by [128]. | |||
| Pancreas in total | SGLT2 mRNA expression [19]. |