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Rupintrivir adopts a new conformation. The inhibitor (shown in sticks) and the 3C proteases (shown in cartoon) of HRV-2, HRV-C15, EV71 and CVA16 are colored orange, blue, red and green, respectively. The transparency of the cartoon representation of 3C proteases of HRV-2, EV71 and CVA16 is 0.7. Insets correspond to zoomed-in views of boxed regions and illustrate the conformational changes of the inhibitor with the rotation angles labeled.
