Table 10.
Current ongoing clinical trials demonstrating the benefits of Povidone-Iodine (PVP–I) as intranasal and gargling use against COVID-19 patients [188].
| NCT Number | Study title | Study design | Intervention | Location |
|---|---|---|---|---|
| NCT04364802 | COVID-19: Povidone-Iodine Intranasal Prophylaxis in Front-line Healthcare Personnel and Inpatients | Phase 2; 250 participants, nonrandomized |
Povidone-Iodine nasal spray and gargle. | University of Kentucky Lexington, Kentucky, United States. |
| NCT04347954 | PVP-I Nasal Sprays and SARS-CoV-2 Nasopharyngeal Titers (for COVID-19) | Phase 1/2; 45 participants; randomized |
Povidone-Iodine 2%. Povidone-Iodine 0.5%. Isotonic saline 0.9%. |
Stanford Health Care Stanford, California, United States. |
| NCT04344236 | Gargling and Nasal Rinses to Reduce Oro- and Nasopharyngeal Viral Load in Patients With COVID-19 | Phase 2; 48 participants; randomized. |
Saline oral/nasal rinse. 0.5% Povidone/Iodine oral/nasal rinse. 0.12% Chlorhexidine oral/nasal rinse. |
NYU Langone Health New York, New York, United States. |
| NCT04371965 | Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Naso- Pharyngeal Viral Load in Patients With COVID-19 (KILLER) | Phase 2; 24 participants; randomized |
Parallel Assignment, Povidone-Iodine |
Poitiers University Hospital, France |
| NCT04410159 | Povidone-Iodine Vs Essential Oil Vs Tap Water Gargling For COVID-19 Patients (GARGLES) | Phase 2; 20 participants; randomized |
Povidone-Iodine Essential oils Tap water |
Universiti Sains Islam Malaysia |
| NCT04449965 | Povidone-Iodine Rinses in the Management of COVID-19 | Early Phase 1; 81 participants; randomized |
Povidone-Iodine Placebo |
St. Paul's Hospital, Canada |
| NCT04393792 | SINUS WASH Pilot Study in Adults Testing Positive for COVID-19 | Early Phase 1; 40 participants; randomized |
Povidone-Iodine Normal saline |
Hampshire Hospitals NHS Foundation trust, United kingdom |
| NCT04446104 | A Preventive Treatment for Migrant Workers at High-risk of Covid-19 | Phase 3; 5000 participants; randomized |
Povidone-Iodine Hydroxychloroquine Sulfate Tablets Ivermectin 3 mg tablet Zinc Vitamin C |
National University Hospital, Singapore. |
| NCT04341688 | A Clinical Trial of Gargling Agents in Reducing Intraoral Viral Load Among COVID-19 Patients (GARGLES) | Phase not applicable; 50 participants; randomized |
Gargle/mouthwash | University of Karachi, Pakistan |