Table 5.

Toxicity status of PVP [50,57,60].

Toxicity	Claim/Evidence	Animal models/Humans
Teratogenicity, Prenataltoxicity	No	Rabbits, Rats
Embryo-toxicity	No	Rabbits embryos
Mutagenicity/Genotoxicity	No	Mice, In vitro cell lines
Carcinogenicity	No (earlier reports claimed tumors, but later found to be erroneous observations)	Rabbits, Rats
Oral toxicity	No	Rabbits, Rats, Dogs, Humans
Intravenous toxicity	Storage disease, Foam cells	Humans
Subcutaneous toxicity	Storage disease, Foam cells	Humans
Intramuscular toxicity	Subcutaneous granuloma	Humans
Inhalation toxicity	Thesaurosis reported (unproven)	Humans
Ocular toxicity	No	Humans
Dermal toxicity	No	Humans
Phototoxicity	No	Humans
Photoallergenicity	No	Humans