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. 2020 Sep 1;10:14348. doi: 10.1038/s41598-020-71144-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptomic landscape of AΦ with PM_2.5 exposure. (a) Heat map of all significantly differentially expressed genes in AΦ and lung monocytes, of CD45.2 and CD45.1 origin from 4- and 32-weeks of FA and PM_2.5 exposed mice. (b) Quantitative Venn diagram showing unique and common DEGs at 4- and 32-weeks of exposure. (c–e) Volcano plots of different pairwise comparisons showing, up- (red) and downregulated (blue) genes. In each volcano plot, top listed genes are ten Hallmark genes and/or immunological signature genes. (f) Quantitative Venn diagram showing unique and common DEGs in TR-AΦ and BM-AΦ at 32-weeks exposure. (g, h) Common and unique significant DEGs in four-way plots showing the effect of (d) PM_2.5 vs FA exposure, and (e) exposure time (4- and 32-weeks). Fold change (Log₂) values are plotted for respective comparisons mentions on the x- and y-axes. Data were generated using three mice from each group.