Table 2.
SNPs associated with telomere length.
| SNP | Gene | Chr | Position | EA | OA | EAF | β (SE) | Base pairsa | Discovery Pvalue | Discovery study |
|---|---|---|---|---|---|---|---|---|---|---|
| rs412658 | ZNF676 | 19 | 22,359,440 | T | C | 0.35 | 0.086 (0.010) | 103.2 | 1.00 × 10−8 | Mangino34 |
| rs8105767 | ZNF208 | 19 | 22,032,639 | G | A | 0.28 | 0.064 (0.011) | 76.8 | 1.11 × 10−9 | Codd35 |
| rs3027234 | CTC1 | 17 | 8,232,774 | C | T | 0.78 | 0.103 (0.012) | 123.6 | 2.00 × 10−8 | Mangino34 |
| rs9420907 | OBFC1 | 10 | 103,916,707 | C | A | 0.13 | 0.142 (0.014) | 170.4 | 7.00 × 10−11 | Levy45 |
| rs755017 | ZBTB46 | 20 | 62,421,622 | G | A | 0.12 | 0.019 (0.013) | 22.8 | 6.71 × 10−9 | Codd35 |
| rs6028466 | DHX35 | 20 | 39,500,359 | A | G | 0.07 | 0.058 (0.013) | 69.6 | 2.57 × 10−8 | Haycock23 |
| rs7675998 | NAF1 | 4 | 163,086,668 | G | A | 0.76 | 0.048 (0.012) | 57.6 | 4.35 × 10−16 | Codd35 |
| rs10936599 | TERC | 3 | 169,774,313 | C | T | 0.76 | 0.100 (0.011) | 120 | 3.00 × 10−31 | Codd35 |
| rs11125529 | ACYP2 | 2 | 54,248,729 | A | C | 0.11 | 0.065 (0.012) | 78 | 8.00 × 10−10 | Codd35 |
| rs6772228 | PXK | 3 | 58,390,292 | T | A | 0.96 | 0.041 (0.014) | 49.2 | 3.91 × 10−10 | Haycock23 |
| rs2736100 | TERT | 5 | 1,286,401 | C | A | 0.5 | 0.085 (0.013) | 102 | 4.38 × 10−19 | Codd35 |
EA effect allele, OA other allele, EAF effect allele frequency in the Caucasian population, β (SE) estimate of telomere length variation for each copy of EA.
aBase pairs: estimate in base pairs of telomere length variation for each copy of EA, as described in Codd35.