Table 4.
association between single SNPs and MM risk.
| SNP | Gene | Allele | MAF | Allelic modela | Codominant modelb | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M/m | OR | 95% CI | PValue | ORHet | 95% CI | PValue | ORHom | 95% CI | PValue | |||
| rs412658 | ZNF676 | C/T | 0.35 | 1.07 | 0.89–1.28 | 0.497 | 1.16 | 0.88–1.51 | 0.290 | 1.07 | 0.71–1.59 | 0.746 |
| rs8105767 | ZNF208 | A/G | 0.28 | 1.09 | 0.90–1.32 | 0.380 | 0.97 | 0.74–1.25 | 0.797 | 1.41 | 0.90–2.20 | 0.136 |
| rs3027234 | CTC1 | C/T | 0.22 | 1.01 | 0.83–1.24 | 0.906 | 1.18 | 0.91–1.52 | 0.207 | 0.69 | 0.38–1.24 | 0.220 |
| rs9420907 | OBFC1 | A/C | 0.13 | 1.43 | 1.15–1.77 | 1.35 × 10−3 | 1.32 | 0.99–1.75 | 0.053 | 2.42 | 1.33–4.38 | 3.62 × 10−3 |
| rs755017 | ZBTB46 | A/G | 0.12 | 0.86 | 0.64–1.14 | 0.291 | 0.77 | 0.55–1.06 | 0.103 | 1.73 | 0.54–5.57 | 0.356 |
| rs6028466 | DHX35 | G/A | 0.07 | 1.12 | 0.81–1.53 | 0.495 | 1.18 | 0.83–1.67 | 0.366 | 0.81 | 0.19–3.48 | 0.776 |
| rs7675998 | NAF1 | G/A | 0.24 | 1.05 | 0.86–1.28 | 0.645 | 1.04 | 0.81–1.33 | 0.787 | 1.13 | 0.66–1.95 | 0.653 |
| rs10936599 | TERC | C/T | 0.24 | 1.1 | 0.89–1.35 | 0.380 | 1.14 | 0.88–1.47 | 0.316 | 1.08 | 0.61–1.94 | 0.786 |
| rs11125529 | ACYP2 | C/A | 0.11 | 0.89 | 0.67–1.16 | 0.374 | 0.94 | 0.70–1.26 | 0.693 | 0.45 | 0.13–1.56 | 0.209 |
| rs6772228 | PXK | T/A | 0.04 | 1.64 | 0.97–2.70 | 0.063 | 1.56 | 0.92–2.63 | 0.099 | – | – | – |
| rs2736100 | TERT | A/C | 0.5 | 1.33 | 1.12–1.59 | 1.49 × 10−3 | 1.69 | 1.27–2.22 | 2.89 × 10−4 | 1.67 | 1.18–2.38 | 4.21 × 10−3 |
Results in bold are statistically significant.
MAF minor allele frequency, OR odds ratio, 95% CI 95% coefficient interval.
aAllelic model: M vs m, common allele vs rare allele.
bCodominant model: Mm vs MM, heterozygous vs common homozygous; mm vs MM, rare homozygous vs common homozygous.
cDominant model: mm vs Mm + MM, rare homozygous vs heterozygous + common homozygous.
dRecessive model: mm + Mm vs MM, rare homozygous + heterozygous vs common homozygous.