Table 2.
Single nucleotide polymorphisms in AMD.
| Genes | SNP | A1 | A2 | F_A1 | F_U | p-value | OR | 95% CI | FDR BH |
|---|---|---|---|---|---|---|---|---|---|
| C2 | rs1883025 | C | G | 0.018 | 0.052 | 0.28 | 0.34 | (0.067, 1.72) | 0.31 |
| C3 | rs4420638 | C | G | 0.25 | 0.16 | 0.10 | 1.74 | (0.91, 3.35) | 0.25 |
| CETP | rs10490924 | A | C | 0.34 | 0.35 | 0.89 | 0.93 | (0.54, 1.61) | 0.85 |
| CFB1 | rs4151667 | A | T | 0.027 | 0.052 | 0.50 | 0.51 | (0.13, 2.11) | 0.51 |
| CFB2 | rs641153 | T | C | 0.12 | 0.094 | 0.67 | 1.28 | (0.55, 2.99) | 0.76 |
| CFB3 | rs12614 | A | G | 0.027 | 0.13 | 0.0057 | 0.19 | (0.053, 0.67) | 0.015 |
| CFH1 | rs800292 | A | G | 0.24 | 0.082 | 0.0012 | 3.45 | (2.31, 5.63) | 0.0048 |
| CFH2 | rs1410996 | A | G | 0.39 | 0.16 | 0.00019 | 3.21 | (2.16, 4.85) | 0.00091 |
| CFH3 | rs1061170 | T | C | 0.60 | 0.34 | 0.000064 | 3.03 | (1.89, 4.57) | 0.00085 |
| CFI | rs10033900 | C | T | 0.55 | 0.45 | 0.18 | 1.48 | (0.87, 2.50) | 0.31 |
| COL8A1 | rs13095226 | C | T | 0.13 | 0.11 | 0.83 | 1.16 | (0.52, 2.58) | 0.85 |
| HTRA1 | rs11200638 | A | G | 0.51 | 0.26 | 0.00012 | 2.97 | (1.70, 5.20) | 0.00085 |
| LIPC | rs10468017 | T | C | 0.28 | 0.29 | 0.88 | 0.95 | (0.53, 1.68) | 0.85 |
| TIMP3 | rs9621532 | C | A | 0.0091 | 0.034 | 0.37 | 0.26 | (0.028, 2.34) | 0.31 |
| TNFRSF10A | rs13278062 | C | A | 0.41 | 0.5 | 0.18 | 0.69 | (0.41, 1.17) | 0.31 |
| VEGF A | rs1413711 | T | C | 0.47 | 0.46 | 0.89 | 1.07 | (0.63, 1.80) | 0.85 |
A1 minor allele, A2 major allele, F_A1 frequency of A1 in AMD, F_U frequency of A1 in controls, FDR BH false discovery rate correction using the Benjamini–Hochberg procedure, OR odds ratio for A1.