Table 1.
Half-maximal inhibitory concentrations (IC50s) of honeybee venom and melittin.
| Cell line | Subtype | Honeybee venom IC50 (ng/μL) | Melittin IC50 (ng/μL) | Melittin IC50 (μM) |
|---|---|---|---|---|
| Human | ||||
| HDFa | Normal | 22.17 ± 1.91 | 7.45 ± 0.12 | 2.62 ± 0.04 |
| MCF 10 A | Normal | 14.38 ± 0.47 | 2.94 ± 0.20 | 1.03 ± 0.07 |
| MCF-12A | Normal | 12.00 ± 1.01 | 5.88 ± 0.41 | 2.07 ± 0.14 |
| MCF7 | Luminal A | 10.77 ± 0.22 | 4.68 ± 0.12 | 1.64 ± 0.04 |
| T-47D | Luminal A | 9.21 ± 0.69 | 10.36 ± 0.43 | 3.64 ± 0.15 |
| ZR-75-1 | Luminal A | 8.32 ± 0.20 | 6.01 ± 0.18 | 2.11 ± 0.06 |
| MDA-MB-231 | TNBC, claudin-low | 8.58 ± 0.39 | 3.24 ± 0.03 | 1.14 ± 0.01 |
| SUM149 | TNBC, basal-like | 6.86 ± 0.45 | 2.67 ± 0.27 | 0.94 ± 0.10 |
| SUM159 | TNBC, claudin-low | 5.58 ± 0.33 | 4.24 ± 0.14 | 1.49 ± 0.05 |
| MDA-MB-453 | HER2-enriched | 7.46 ± 0.07 | 4.03 ± 1.20 | 1.42 ± 0.42 |
| SKBR3 | HER2-enriched | 5.77 ± 0.51 | 3.59 ± 0.24 | 1.26 ± 0.09 |
| Murine | ||||
| NIH/3T3 | Normal | 11.7 ± 0.81 | 4.51 ± 0.18 | 1.58 ± 0.06 |
| BRCA− B.15 | Basal-like | 6.42 ± 0.44 | 2.36 ± 0.19 | 0.83 ± 0.06 |
| p53− T11 | Claudin-low | 6.24 ± 0.49 | 2.08 ± 0.08 | 0.73 ± 0.03 |
Data are presented as mean ± SEM in ng/μL or μM (to two decimal places). Experiments were performed in biological triplicates. TNBC triple-negative breast cancer, HER2 human epidermal growth factor receptor 2.