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. 2020 May 28;1(1):tgaa019. doi: 10.1093/texcom/tgaa019

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hippocampal rsFC strength is inversely associated with SMD severity. The 115 connections between hippocampal and Power ROIs showing an inverse relationship with CCI score are displayed on the Circos graph. No positive relationships were found. The number of connections between the right body of the hippocampus and other brain regions showing an inverse relationship with SMD relative to the number of connections between the other hippocampal regions and the rest of the brain showing an inverse relationship with SMD severity combined was greater than chance. The number of connections between the right body of the hippocampus and regions in the SOM, AUD, COTCN, FPTCN, DAN, and DMN inversely associated with SMD severity was significantly greater than chance and survived correction for multiple comparisons. The nodes representing the brain regions within these 6 networks whose connection strength with the right body of the hippocampus showed an inverse relationship with SMD severity are displayed on the right on cortical surfaces created in Brain Net Viewer v1.6 (Xia et al. 2013).