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. 2020 Sep 1;11:4384. doi: 10.1038/s41467-020-18132-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Colour-coded schematic representation of DNA nanostructure designs – ConA is a solid tile and ConB and ConC are frame-like with different central cavities. All three structures feature similar external dimensions but varying internal cavity. b AFM micrographs of the respective nanostructures and c their typical translocation ion current signatures. d Scatter plot of individual translocation events with peak amplitude plotted versus dwell time for ConA (blue circles), ConB (green circles) and ConC (black circles), overlaid with the respective 95% confidence ellipses. Source data are in the Source Data file.