Figure 5.

Effect size of eQTL is lower in genes and miRNA that are differentially expressed. The allelic effect size is significantly lower (P < 2.22 × 10⁻¹⁶) in genes that are differentially expressed in both cis- and trans-eQTL. (A) For cis-eQTL, the median variance explained when the transcript is differentially expressed is 0.186 compared to 0.238 when it is not differentially expressed. (B) For trans-eQTL, the median variance explained when the transcript is differentially expressed is 0.124 compared to 0.143 when it is not differentially expressed. (C) The allelic effect size is not significantly different in cis or trans-mirQTL; however, the median of differentially expressed cis-mirQTL is 0.139 compared to 0.169 when not differentially expressed. (D) Similarly, differentially expressed mirQTL in trans had a smaller median than those not differentially expressed at 0.127 and 0.141, respectively.