. 2020 Jul 18;14(9):1947–1965. doi: 10.1002/1878-0261.12741

Table 1.

Correlation of immune checkpoints expression and immune cell infiltration. n: number of patients; r: Correlation Coefficient; P: probability value; Primary: primary tumor; Stroma: tumor stroma area; Tumor: tumor nest including intratumoral area.

			Primary tumor cell density (cell·mm⁻²)						LN metastasis cell density (cell·mm⁻²)
			CD45⁺		CD3⁺		CD8⁺		CD45⁺		CD3⁺		CD8⁺
			Stroma	Tumor	Stroma	Tumor	Stroma	Tumor	Stroma	Tumor	Stroma	Tumor	Stroma	Tumor
Primary	PVR expression	r	0.399 ^a	0.529 ^b	0.360 ^a	0.426 ^a	0.406 ^a	0.500 ^b	0.25	0.12	0.34	0.20	0.30	0.21
		P	0.012	0.001	0.024	0.011	0.011	0.004	0.320	0.640	0.159	0.421	0.219	0.413
		n	24	24	24	24	24	24	18	18	19	18	19	18
	IDO stroma endothelium	r	0.782 ^b	0.870 ^b	0.851 ^b	0.907 ^b	0.872 ^b	0.797 ^b	−0.25	−0.04	−0.07	−0.01	−0.03	0.04
		P	0.000	0.000	0.000	0.000	0.000	0.000	0.309	0.865	0.754	0.956	0.904	0.878
		n	23	23	23	23	23	23	19	18	20	18	20	18
	IDO stroma nonendothelial cell	r	0.702 ^b	0.770 ^b	0.757 ^b	0.790 ^b	0.772 ^b	0.697 ^b	−0.22	−0.06	−0.03	0.01	0.02	0.10
		P	0.000	0.000	0.000	0.000	0.000	0.000	0.367	0.817	0.899	0.954	0.919	0.686
		n	23	23	23	23	23	23	19	18	20	18	20	18
	IDO tumor	r	0.722 ^b	0.796 ^b	0.767 ^b	0.829 ^b	0.812 ^b	0.801 ^b	−0.04	0.24	0.12	0.33	0.16	0.29
		P	0.000	0.000	0.000	0.000	0.000	0.000	0.858	0.339	0.606	0.180	0.491	0.252
		n	23	23	23	23	23	23	19	18	20	18	20	18
LN	PVR expression	r	−0.10	−0.03	−0.12	−0.10	−0.12	−0.25	0.527 ^b	0.507 ^b	0.355 ^a	0.543 ^b	0.30	0.521 ^b
		P	0.619	0.901	0.570	0.638	0.558	0.234	0.002	0.003	0.035	0.002	0.076	0.004
		n	25	24	25	24	25	24	22	22	22	22	22	22
	IDO stroma endothelium	r	−0.39	−0.08	−0.20	0.09	−0.17	−0.07	0.806 ^b	0.641 ^b	0.450 ^a	0.515 ^a	0.542 ^b	0.523 ^a
		P	0.062	0.720	0.341	0.671	0.415	0.762	0.000	0.001	0.031	0.012	0.006	0.010
		n	24	23	24	23	24	23	23	23	23	23	23	23
	IDO stroma nonendothelial cell	r	−0.22	−0.06	−0.09	0.10	−0.02	0.17	0.801 ^b	0.779 ^b	0.636 ^b	0.665 ^b	0.681 ^b	0.679 ^b
		P	0.299	0.772	0.686	0.634	0.914	0.432	0.000	0.000	0.003	0.001	0.000	0.000
		n	24	23	24	23	24	23	23	23	23	23	23	23
	IDO tumor	r	−0.22	0.01	−0.06	0.19	−0.05	−0.05	0.661 ^b	0.689 ^b	0.30	0.558 ^b	0.40	0.581 ^b
		P	0.306	0.981	0.776	0.386	0.809	0.815	0.001	0.000	0.171	0.006	0.053	0.004
		n	24	23	24	23	24	23	22	23	23	23	23	23

^{^a}

Correlation is significant at the 0.05 level (two‐tailed Spearman test).

^{^b}

Correlation is significant at the 0.01 level (two‐tailed Spearman test).