Table 1.
Single nucleotide variants (SNVs) in solid tumor lesions (ovarian masses and metastases), tumor cell spheroids from ascites, and cultured OCMI cells from the same spheroids. Samples from 3 patients were included (OC38, OC122, and OC137). Solid tumor lesions were not analyzed for OC137.
| Sample | Locus | Amino acid altered | SNV frequency |
|---|---|---|---|
| OC38 | |||
| Solid tumor lesions | RAD51D | T99A | 0.10 – 0.32 |
| Spheroids from ascites | RAD51D | T99A | 0.014 |
| Cultured cells (OCMI38) | RAD51D | T99A | 0.49 |
| OC122 | |||
| Solid tumor lesions | ADAMTS7 | N1071S | 0.08 – 0.20 |
| ADAMTS7 | Y1078fs | 0.10 – 0.24 | |
| TP53 | C277G | 0.06 – 0.48 | |
| Spheroids from ascites | ADAMTS7 | N1071S | 0.17 |
| ADAMTS7 | Y1078fs | 0.18 | |
| TP53 | C277G | 0.80 | |
| Cultured cells (OCMI 122) | ADAMTS7 | N1071S | 0.14 |
| ADAMTS7 | Y1078fs | 0.17 | |
| TP53 | C277G | 0.00 | |
| OC137 | |||
| Spheroids from ascites | TP53 | R248W | 0.93 |
| Cultured cells (OCMI 137) | TP53 | Mutated (p53 protein stabilized; see Fig. S2) | |