Table 2.
Assessment of diagnostic value of DNA methylation markers. CI, confidence interval.
| Test | Sample type | Disease + (n) | Controls (n) | Fisher's exact test P‐value (two‐sided) | Sensitivity | Specificity | Relative risk (95% CI) a | Diagnostic odds ratio (95% CI) a | Diagnostic accuracy (%) | Positive predictive value (95% CI) | Negative predictive value (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cytology | BW | 90 | 31 | < 0.0001 | 0.59 (0.49–0.69) | 1.00 (0.89–1.00) | 1.84 (1.48–2.28) | 89.9 (5.3–1516) | 69 | 1.00 (0.93–1.00) | 0.46 (0.33–0.58) |
| CDH1 | BW | 90 | 31 | 0.0001 | 0.64 (0.54–0.74) | 0.74 (0.55–0.88) | 1.51 (1.19–1.92) | 5.2 (2.1–13.0) | 68 | 0.88 (0.77–0.94) | 0.42 (0.29–0.56) |
| DLC1 | BW | 69 | 27 | 0.0027 | 0.37 (0.26–0.48) | 0.94 (0.79–0.99) | 1.48 (1.22–1.79) | 8.4 (1.9–37.8) | 53 | 0.94 (0.79–0.99) | 0.37 (0.26–0.48) |
| PRPH | BW | 79 | 30 | < 0.0001 | 0.40 (0.30–0.51) | 1.00 (0.89–1.00) | 1.57 (1.34–1.85) | 42.2 (2.5–712) | 56 | 1.00 (0.90–1.00) | 0.36 (0.27–0.48) |
| RASSF1A | BW | 91 | 31 | < 0.0001 | 0.46 (0.35–0.56) | 1.00 (0.89–1.00) | 1.63 (1.37–1.94) | 52.8 (3.1–890) | 60 | 1.00 (0.91–1.00) | 0.39 (0.28–0.50) |
| RASSF1A/ CDH1/ PRPH/ DLC1 | BW | 91 | 31 | < 0.0001 | 0.97 (0.91–0.99) | 0.74 (0.55–0.88) | 7.33 (2.54–21.2) | 76.1 (18.6–312) | 88 | 0.92 (0.84–0.96) | 0.87 (0.68––0.97) |
a
Since the values of the contingency table included a zero, the odds ratio was calculated by adding 0.5 to each value of the table.