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. 2020 Jul 11;14(9):2069–2080. doi: 10.1002/1878-0261.12755

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© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Differences in the mutational landscape and DNA methylation between reformed smokers and current smokers. (A) Top 20 differentially mutated genes between reformed smokers and current smokers. (B) The expression of GPATCH8 and ZFC3H1 was significantly associated with their somatic mutations using the Mann–Whitney U‐test. The error bar was SD. (C) Genes with different CNV and their copy number gains or loss mainly on chromosomes 19, 1, and 17. (D) Genes in reformed smoker with different DNA methylation compared to current smokers. (E) Expression of HOXB2 and PTHLH was significantly associated with methylation level by the Pearson correlation coefficient.