Table 2.
The association between the smoking signature and patients' overall survival a .
| Cancer type | Age‐adjusted HR (95% CI) | P‐value | MV‐adjusted HR (95% CI) b | P‐value |
|---|---|---|---|---|
| BLCA | 1.03 (1.01–1.05) | 0.001 | 1.70 (1.01–2.88) | 0.048 |
| CESC c | 4.69 (1.80–12.23) | 0.002 | 5.69 (1.37–23.69) | 0.017 |
| ESCA | 1.22 (0.50–3.01) | 0.663 | 1.30 (0.50–3.41) | 0.596 |
| HNSC c | 2.14 (1.55–2.96) | < 0.001 | 1.97 (1.41–2.76) | < 0.001 |
| LUAD | 1.52 (1.07–2.17) | 0.020 | 1.73 (1.16–2.57) | 0.007 |
| LUSC | 1.85 (1.29–2.64) | 0.001 | 1.70 (1.19–2.43) | 0.003 |
| PAAD | 5.90 (2.60–13.41) | < 0.001 | 4.28 (1.47–12.47) | 0.008 |
Significant associations are shown in bold.
a
The smoking signature is the continuous variable.
b
MV‐adjusted for age (continuous), gender (female, male), tumor stage (stage Ⅰ, stage Ⅱ, stage Ⅲ, and stage Ⅳ), and tumor status (with tumor and tumor‐free).
c
MV‐adjusted for age (continuous), gender (female, male), tumor stage (stage Ⅰ, stage Ⅱ, stage Ⅲ, and stage Ⅳ), tumor status (with tumor and tumor‐free), and HPV status (positive and negative).