Table 2.
Summary of gene expression profiles in aortic tissue. Results are presented in arbitrary units normalized to GAPDH rRNA and shown as mean ± standard deviation (n = 5 per group).
| Sham | Control | AQ | AC | |
|---|---|---|---|---|
| VEGF-A | 0.54 ± 0.04 | 2.94 ± 0.16∗ | 1.82 ± 0.20∗# | 1.34 ± 0.10∗# |
| ICAM-1 | 1.04 ± 0.12 | 4.15 ± 0.09∗ | 2.87 ± 0.15∗# | 3.14 ± 0.12∗# |
| VCAM-1 | 0.75 ± 0.04 | 3.47 ± 0.12∗ | 2.65 ± 0.16∗# | 2.43 ± 0.19∗# |
| VE-cadherin | 1.15 ± 0.10 | 5.42 ± 0.18∗ | 4.35 ± 0.09∗# | 3.54 ± 0.20∗# |
| TGF1 | 1.46 ± 0.16 | 1.32 ± 0.09 | 1.41 ± 0.11 | 1.61 ± 0.22 |
| FGF | 0.53 ± 0.05 | 0.34 ± 0.15 | 0.41 ± 0.14 | 0.38 ± 0.12 |
| COX-2 | 1.14 ± 0.13 | 3.67 ± 0.11∗ | 2.74 ± 0.15∗# | 1.56 ± 0.09∗# |
| HIF-1α | 0.95 ± 0.14 | 6.51 ± 0.39∗ | 4.85 ± 0.27∗# | 3.23 ± 0.25∗# |
Abbreviations: VEGF-A: vascular endothelial growth factor-A; ICAM-1: intercellular adhesion molecule-1; VCAM-1: vascular cell adhesion molecule 1; VE-cadherin: vascular endothelial cadherin; TGF1: transforming growth factor-1; FGF: fibroblast growth factor; COX-2: cyclooxygenase-2; HIF-1α: hypoxia-inducible factor 1α. ∗P < 0.05 vs. sham, #P < 0.05 vs. control.