Table A3.
Metabolites associated with both body composition measures.
| Biochemical | Sub Pathway | β Body Mass Index | 95% CI | p (FDR) | β Body Fat Percent | 95% CI | p (FDR) |
|---|---|---|---|---|---|---|---|
| Super-pathway: Amino Acid | |||||||
| guanidinosuccinate | Guanidino and acetamido metabolism | 0.971 | 0.957 to 0.986 | 0.046 | 0.977 | 0.967 to 0.987 | 0.014 |
| isobutyrylglycine (C4) | Leucine, isoleucine, and valine metabolism | 0.967 | 0.954 to 0.979 | 0.002 | 0.976 | 0.967 to 0.985 | 0.001 |
| isovalerylglycine | Leucine, isoleucine, and valine metabolism | 0.965 | 0.953 to 0.976 | 0.000 | 0.972 | 0.964 to 0.980 | 0.000 |
| tigloylglycine | Leucine, isoleucine, and valine metabolism | 0.974 | 0.961 to 0.987 | 0.036 | 0.974 | 0.965 to 0.983 | 0.000 |
| Super-pathway: CV | |||||||
| Nicotinamide N-oxide | Nicotinate and nicotinamide metabolism | 1.050 | 1.025 to 1.075 | 0.030 | 1.043 | 1.026 to 1.060 | 0.001 |
| Super-pathway: PCM | |||||||
| Glucuronide of C10H18O2 (12) * | Partially characterized molecules | 1.047 | 1.029 to 1.066 | 0.001 | 1.028 | 1.015 to 1.041 | 0.016 |
| Super-pathway: Unknown | |||||||
| X-21851 | 1.038 | 1.020 to 1.057 | 0.021 | 1.025 | 1.012 to 1.038 | 0.044 | |
| X-24469 | 1.035 | 1.018 to 1.052 | 0.025 | 1.023 | 1.011 to 1.035 | 0.044 | |
| X-24801 | 1.032 | 1.017 to 1.047 | 0.016 | 1.024 | 1.014 to 1.034 | 0.004 | |
| Super-pathway: XB | |||||||
| Succinimide | Chemical | 0.976 | 0.965 to 0.986 | 0.011 | 0.985 | 0.978 to 0.993 | 0.046 |
Estimates were generated from linear regression models with natural log-transformed biochemicals as the dependent variables, and body mass index or body fat percent as the dependent variable. Multiple testing adjustment was performed by controlling the false discovery rate at 5%. Estimates are back-transformed. The models were additionally adjusted for age, calories consumed, protein consumed, carbohydrates consumed, fat consumed, maternal gestational weight gain, maternal BMI, breastfeeding duration, smoking status, smoking household, alcohol status, maternal occupation, maternal education, metabolic equivalent of task-hours. * Compound was not identified by a standard, but we are confident in its identity. Abbreviations: CV, cofactors and vitamins; PCM, partially characterized molecules; XB, xenobiotics; FDR, False Discovery Rate.