Table 2.
Application of adipose—Derived stem cells in human clinical trials.
| Study Title [Reference] |
Type of Study | Number of Participants | Medical Condition | Source of ASCs | First Author, (Year) |
|---|---|---|---|---|---|
| Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: A randomized controlled trial [122] | Randomized, controlled trial | 30 | Knee osteoarthritis | Autologous | Freitag, (2019) |
| Subtalar arthrodesis with use of adipose-derived cellular bone matrix compared with autologous bone graft: A multicenter, randomized controlled trial [125] | Prospective, randomized, controlled trial | 140 | Subtalar joint arthritis | Allogeneic | Myerson, (2019) |
| Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study [126] | Single-arm phase I clinical trial | 10 | Chronic discogenic low back pain | Autologous | Kumar, (2017) |
| Safety and efficacy of mesenchymal stem cells for radiation-induced xerostomia: A randomized, placebo-controlled phase 1/2 trial (MESRIX) [127] | Prospective, randomized, controlled phase 1/2 trial | 30 | Radiation-induced xerostomia | Autologous | Grønhøj, (2018) |
| Potential of allogeneic adipose-derived stem cell-hydrogel complex for treating diabetic foot ulcer [129] | Randomized, controlled trial | 59 | Diabetic foot ulcer | Allogeneic | Moon, (2019) |
| Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn’s disease: A phase 3 randomized, double-blind controlled trial [130] | Phase 3 randomized, double-blind controlled trial | 212 | Complex perianal fistulas in Crohn’s disease | Allogeneic | Panés, (2016) |
| Early results of a phase I trial using an adipose-derived mesenchymal stem cell-coated fistula plug for the treatment of transsphincteric cryptoglandular fistulas [134] | Phase I clinical trial | 15 | Transsphincteric cryptoglandular fistulas | Autologous | Dozois, (2019) |
| Lateral ramus cortical bone plate in alveolar cleft osteoplasty with concomitant use of buccal fat pad-derived cells and autogenous bone: Phase І clinical trial [137] | Phase I clinical trial | 10 | Alveolar cleft defects | Allogeneic | Khojasteh, (2017) |
| Cryopreserved off-the-shelf allogeneic adipose-derived stromal cells for therapy in patients with ischemic heart disease and heart failure: A safety study [141] | Phase I clinical trial | 10 | Ischemic heart disease and heart failure | Allogeneic | Kastrup, (2017) |
| Autologous mesenchymal stem cells increase cortical perfusion in renovascular disease [142] | Phase 1/2A clinical study | 28 | Atherosclerotic renovascular disease | Autologous | Saad, (2017) |
| Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy [145] | Phase I/II clinical study | 24 | Multiple system atrophy | Autologous | Singer, (2019) |
| Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study [146] | Triple blinded, controlled, randomized phase I/II study | 34 | Multiple sclerosis | Autologous | Fernández, (2018) |
| Stem cell enriched lipotransfer reverses the effects of fibrosis in systemic sclerosis [147] | Single-arm experimental study | 62 | Systemic sclerosis | Autologous | Almadori, (2019) |
| Corneal stroma enhancement with decellularized stromal laminas with or without stem cell recellularization for advanced keratoconus [148] | Phase I clinical trial | 9 | Keratoconus | Autologous | Alió del Barrio, (2018) |