Changes of central retinal thickness (CRT) from initial treatment according to the groups. In pachydrusen group, CRT significantly decreased from 408 ± 171 (baseline) to 190 ± 98, 185 ± 82, 190 ± 86, 202 ± 113 at 3 months, 6 months, 9 months, and 12 months, respectively. (all p-value < 0.001) In no drusen group, CRT significantly decreased from 373 ± 160 (baseline) to 202 ± 81, 210 ± 71, 215 ± 75, 218 ± 85 at 3 months, 6 months, 9 months, and 12 months, respectively. (all p-value < 0.001) In soft drusen group, CRT significantly decreased from 406 ± 210 (baseline) to 196 ± 69, 240 ± 113, 229 ± 114, 236 ± 122 at 3 months, 6 months, 9 months, and 12 months, respectively. (all p-value < 0.001) In PCV/Scarring group, CRT significantly decreased from 434 ± 132 (baseline) to 242 ± 99, 254 ± 114, 245.0 ± 84, 234 ± 83 at 3 months, 6 months, 9 months, and 12 months, respectively. (all p-value < 0.05).