Table 1.

Association of categorical variables on event-free survival (EFS) and OS of the FXIII-A negative vs. dim groups by univariate and multivariate Cox regression analysis

Variables	Event-Free Survival			Overall Survival
	HR	95% CI	p-Value	HR	95% CI	p-Value
	Univariate Analysis
FXIII-A expression pattern
FXIII-A negative	2.91	1.17–7.21	0.021	2.63	0.88–7.84	0.084
FXIII-A dim	0.34	0.14–0.85		0.38	0.13–1.14
Age
1–5 years	0.39	0.17–0.92	0.032	0.24	0.08–0.71	0.010
≥6 years	2.56	1.10–6.05		4.20	1.41–12.56
WBC
<20,000	0.69	0.29–1.66	0.407	0.60	0.21–1.71	0.334
≥20,000	1.45	0.60–3.51		1.69	0.58–4.86
Sex
Male	1.53	0.62–3.79	0.360	1.87	0.59–6.00	0.291
Female	0.65	0.26–1.62		0.54	0.17–1.71
prednisone response
PGR	0.27	0.09–0.73	0.010	0.15	0.05–0.45	0.001
PPR	3.75	1.37–10.24		6.71	2.25–20.03
FC risk categories
FLR/FMR	1.43	0.40–5.13	0.581	1.18	0.25–5.54	0.838
FLR/FHR	3.37	0.78–14.58	0.104	3.40	0.62–18.56	0.158
ALLIC BFM 2009 classification
BFM-HR/BFM-SR	0.12	0.01–0.95	0.044	0.00
BFM-HR/BFM-IR	0.41	0.16–1.05	0.063	0.32	0.11–0.92	0.035
Genetic risk categories
good/intermediate	7.12	2.07–24.73	0.002	13.8	1.77–107.9	0.012
good/high	23.7	4.72–119.3	<0.001	63.1	6.50–613.3	<0.001
B-other
Recurrent genetic abnormalities	0.26	0.10–0.68	0.006	0.27	0.08–0.86	0.027
B-other	3.82	1.48–9.86		3.71	1.16–11.85
	Multivariate Analysis
FXIII negative	2.29	0.85–6.20	0.102	1.70	0.51–5.71	0.390
Genetic risk categories
good/intermediate	5.78	1.63–20.52	0.007	10.0	1.24–81.4	0.031
good/high	17.4	2.88–104.8	0.002	30.5	2.63–353.4	0.006

p < 0.05 values were considered statistically significant, such p values are marked in bold.