Table 2.

Association of categorical variables on event-free survival (EFS) and OS of the FXIII-A dim vs. bright groups by univariate and multivariate Cox regression analysis.

Variables	Event-Free Survival			Overall Survival
	HR	95% CI	p-Value	HR	95% CI	p-Value
	Univariate Analysis
FXIII-A expression pattern
FXIII-A dim	0.24	0.09–0.64	0.004	0.32	0.09–1.04	0.057
FXIII-A bright	4.10	1.56–10.78		3.17	0.97–10.38
Age
1–5 years	0.52	0.19–1.37	0.186	0.32	0.10–1.05	0.060
≥6 years	1.92	0.73–5.06		3.13	0.96–10.28
WBC
<20,000	0.67	0.26–1.76	0.417	0.56	0.17–1.84	0.341
≥20,000	1.49	0.57–3.92		1.78	0.54–5.83
Sex
Male	1.43	0.53–3.86	0.483	2.08	0.55–7.86	0.278
Female	0.70	0.26–1.90		0.48	0.18–1.81
prednisone response
PGR	0.34	0.08–1.47	0.146	0.43	0.06–3.41	0.427
PPR	1.43	0.53–3.86		2.08	0.55–7.86
FC risk categories
FLR/FMR	0.90	0.27–2.83	0.857	1.33	0.24–5.54	0.863
FLR/FHR	1.25	0.23–6.81	0.801	2,59	0.36–18.43	0.342
ALLIC BFM 2009 classification
BFM-HR/BFM-SR	0.39	0.098–1.59	0.192	0.17	0.02–1.49	0.110
BFM-HR/BFM-IR	0.27	0.09–0.78	0.015	0.21	0.06–0.73	0.014
Genetic risk categories
good/intermediate	2.08	0.75–5.74	0.051	3.68	0.92–14.73	0.065
good/high	4.86	0.99–23.76	0.157	9.65	1.59–58.42	0.014
B-other
Recurrent genetic abnormalities	0.55	0.21–1.44	0.225	0.41	0.12–1.33	0.137
B-other	1.80	0.70–4.78		2.46	0.75–8.07
	Multivariate Analysis
FXIII-A bright	3.92	1.41–10.84	0.009	3.90	0.99–15.31	0.051
Genetic risk categories
good/intermediate	2.69	0.84–8.55	0.095	6.07	1.17–31.65	0.032
good/high	3.56	0.70–18.03	0.124	7.67	1.21–48.64	0.031

p < 0.05 values were considered statistically significant, such p values are marked in bold.