Table 3.

Association of categorical variables on event-free survival (EFS) and OS of the FXIII-A negative vs. bright groups by univariate and multivariate Cox regression analysis.

Variables	Event-Free Survival			Overall Survival
	HR	95% CI	p-Value	HR	95% CI	p-Value
	Univariate Analysis
FXIII-A expression pattern
FXIII-A negative	0.66	0.29–1.51	0.323	0.80	0.28–2.24	0.665
FXIII-A bright	1.52	0.66–3.47		1.26	0.45–3.54
Age
1–5 years	0.52	0.24–1.17	0.116	0.36	0.13–1.02	0.056
≥6 years	1.90	0.85–4.24		2.75	0.98–7.72
WBC
<20,000	0.49	0.21–1.13	0.093	0.68	0.23–1.98	0.477
≥ 20,000	2.06	0.89–4.76		1.48	0.50–4.32
Sex
Male	1.21	0.53–2.78	0.647	1.43	0.49–4.17	0.518
Female	0.82	0.36–1.89		0.70	0.24–2.05
prednisone response
PGR	0.36	0.13–0.96	0.041	0.28	0.09–0.87	0.028
PPR	2.81	1.04–7.58		3.61	1.15–11.35
FC risk categories
FLR/FMR	2.48	0.72–8.56	0.150	1.90	0.41–8.80	0.411
FLR/FHR	3.29	0.77–13.9	0.106	3.53	0.65–19.28	0.145
ALLIC BFM 2009 classification
BFM-HR/BFM-SR	0.21	0.05–0.97	0.045	0.15	0.02–1.22	0.076
BFM-HR/BFM-IR	0.47	0.20–1.11	0.085	0.37	0.13–1.04	0.060
Genetic risk categories
good/intermediate	2.14	0.89–5.17	0.091	2.50	0.75–8.30	0.135
good/high	6.48	1.69–24.84	0.006	10.5	2.33–47.2	0.002
B-other
Recurrent genetic abnormalities	0.61	0.27–1.36	0.228	0.66	0.24–1.81	0.413
B-other	1.64	0.73–3.67		1.53	0.55–4.21
	Multivariate Analysis
FXIII-A bright	0.54	0.22–1.34	0.108	0.59	0.19–1.88	0.3751
Genetic risk categories
good/intermediate	2.33	0.87–6.22	0.091	2.63	0.68–10.25	0.164
good/high	4.55	1.14–18.15	0.032	7.44	1.54–36.00	0.013

p < 0.05 values were considered statistically significant, such p values are marked in bold.