Table 2.

Metabolites fold change calculated by dividing the mean of each metabolite peak intensity from each of the two groups. Statistical significance was revealed using the non-parametric Mann-Whitney test. Results were considered only significant if p ≤ 0.05 using Kruskal-Wallis test analysis.

Metabolites	Fold Change *
	B/A	C/B	D/B	E/B	F/B	G/B	H/B
Lactic Acid	2.30 *	0.095 *	0.29 *	0.63	0.79	0.46 *	0.80
Oxalic Acid	1.026	0.15 *	1.93	0.42	0.93	0.52	1.15
Pyroglutamic Acid	3.06 *	16.36 *	0.33 *	0.117 *	0.38 *	0.45 *	0.33 *
D-Fructose	2.52*	0.19 *	0.94	0.84	0.98	0.85	1.01
D- Sorbitol	5.77 *	1.027	0.89	0.64	2.46 *	1.47	3.42 *
D-Fructose	21.32 *	0.018 *	0.11 *	0.17 *	0.76	0.31 *	0.48
Arachidonic Acid	0.25 *	7.51 *	3.91 *	2.38	1.44	1.40	1.70
Oleamide	0.051 *	16.84 *	17.53	31.53 *	12.66 *	31.47 *	14.31
Erucylamide	0.23 *	15.90 *	1.99 *	0.92	0.73	0.77	1.49

Statistical comparisons equal the non-parametric Mann-Whitney test was performed. Results were considered only significant if p ≤ 0.05 using Kruskal-Wallis test analysis. Sample codes are presented as follows: (A) negative control, (B) positive control, (C) dexamethasone standard, (D) nano-Ag, (E) ASBE, (F) ASBE plus nano-Ag, (G) ASB nano-extract, and (H) ASB nano extract plus nano-Ag. * Denotes metabolites showing significant difference among treated groups.