Table 2.
Effect of administration of Cur-PLGA-DPPs on the biochemical parameters of the liver (ALP, AST, ALT) and kidney (CRE, BUN) damage markers. Values are presented as mean ± standard deviation (n = 4).
| Parameter | Control | OVA | OVA + Cur-PLGA-DPPs 5 mg/kg |
OVA + Cur-PLGA-DPPs 25 mg/kg |
OVA + Curcumin 4 mg/kg |
|---|---|---|---|---|---|
| ALP (U/L) | 362.0 ± 11.3 | 285.2 ± 36.9 | 296.8 ± 16.6 | 294.0 ± 14.3 | 317.7 ± 26.8 |
| AST (U/L) | 107.5 ± 6.36 | 125.2 ± 53.7 | 116.0 ± 27.4 | 115.3 ± 22.2 | 113.0 ± 9.9 |
| ALT (U/L) | 72.0 ± 32.5 | 57.2 ± 32.9 | 65.5 ± 34.8 | 55.8 ± 7.4 | 48.0 ± 28.3 |
| CRE (mg/dL) | 0.2 ± 0.0 | 0.3 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| BUN (mg/dL) | 27.4 ± 0.1 | 26.4 ± 3.5 | 31.2 ± 3.3 | 20.3 ± 3.4 | 23.7 ± 2.8 |
ALP: alkaline phosphatase, AST: aspartate aminotransferase, ALT: alanine aminotransferase, CRE: creatinine, BUN: blood urea nitrogen.